Highlighted Articles
Eichenberger M, Schwander T, Hüppi S, Kreuzer J, Mittl PRE, Peccati F, Jiménez-Osés G, Naesby M, Buller RM. The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis. Nat Catal. 2023; 6(10):927-938. doi: 10.1038/s41929-023-01018-y. Epub 2023 Aug 31. PMID: 37881531; PMCID: PMC10593608.
Pencik J, Philippe C, Schlederer M, Atas E, Pecoraro M, Grund-Gröschke S, Li WJ, Tracz A, Heidegger I, Lagger S, Trachtová K, Oberhuber M, Heitzer E, Aksoy O, Neubauer HA, Wingelhofer B, Orlova A, Witzeneder N, Dillinger T, Redl E, Greiner G, D’Andrea D, Östman JR, Tangermann S, Hermanova I, Schäfer G, Sternberg F, Pohl EE, Sternberg C, Varady A, Horvath J, Stoiber D, Malcolm TI, Turner SD, Parkes EE, Hantusch B, Egger G, Rose-John S, Poli V, Jain S, Armstrong CWD, Hoermann G, Goffin V, Aberger F, Moriggl R, Carracedo A, McKinney C, Kennedy RD, Klocker H, Speicher MR, Tang DG, Moazzami AA, Heery DM, Hacker M, Kenner L. STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway. Mol Cancer. 2023 Aug 12;22(1):133. doi: 10.1186/s12943-023-01825-8. PMID: 37573301; PMCID: PMC10422794.
García-Vílchez R, Añazco-Guenkova AM, Dietmann S, López J, Morón-Calvente V, D’Ambrosi S, Nombela P, Zamacola K, Mendizabal I, García-Longarte S, Zabala- Letona A, Astobiza I, Fernández S, Paniagua A, Miguel-López B, Marchand V, Alonso-López D, Merkel A, García-Tuñón I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Bárcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sánchez-Martín MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. PMID: 37516825; PMCID: PMC10386714.
Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators Millet O, Mato JM. Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis. Lancet Gastroenterol Hepatol. 2023 Aug;8(8):704-713. doi: 10.1016/S2468-1253(23)00141-3. Epub 2023 Jun 5. PMID: 37290471.
Gonzalez-Rellan MJ, Fernández U, Parracho T, Novoa E, Fondevila MF, da Silva Lima N, Ramos L, Rodríguez A, Serrano-Maciá M, Perez-Mejias G, Chantada-Vazquez P, Riobello C, Veyrat-Durebex C, Tovar S, Coppari R, Woodhoo A, Schwaninger M, Prevot V, Delgado TC, Lopez M, Diaz-Quintana A, Dieguez C, Guallar D, Frühbeck G, Diaz-Moreno I, Bravo SB, Martinez-Chantar ML, Nogueiras R. Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism. Cell Metab. 2023 Sep 5;35(9):1630-1645.e5. doi: 10.1016/j.cmet.2023.07.003. Epub 2023 Aug 3. PMID: 37541251; PMCID: PMC10487638.
Capelo-Diz A, Lachiondo-Ortega S, Fernández-Ramos D, Cañas-Martín J, Goikoetxea-Usandizaga N, Serrano-Maciá M, González-Rellan MJ, Mosca L, Blazquez- Vicens J, Tinahones-Ruano A, Fondevila MF, Buyan M, Delgado TC, Gutierrez de Juan V, Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Fernández-Susavila H, Riobello-Suárez C, Dziechciarz B, Montiel-Duarte C, Lopitz-Otsoa F, Bizkarguenaga M, Bilbao-García J, Bernardo-Seisdedos G, Senra A, Soriano-Navarro M, Millet O, Díaz-Lagares Á, Crujeiras AB, Bao-Caamano A, Cabrera D, van Liempd S, Tamayo-Carro M, Borzacchiello L, Gomez-Santos B, Buqué X, Sáenz de Urturi D, González-Romero F, Simon J, Rodríguez-Agudo R, Ruiz A, Matute C, Beiroa D, Falcon-Perez JM, Aspichueta P, Rodríguez-Cuesta J, Porcelli M, Pajares MA, Ameneiro C, Fidalgo M, Aransay AM, Lama-Díaz T, Blanco MG, López M, Villa- Bellosta R, Müller TD, Nogueiras R, Woodhoo A, Martínez-Chantar ML, Varela-Rey M. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting. Cell Metab. 2023 Aug 8;35(8):1373-1389.e8. doi: 10.1016/j.cmet.2023.07.002. Epub 2023 Jul 31. PMID: 37527658; PMCID: PMC10432853.
Clavería-Cabello A, Herranz JM, Latasa MU, Arechederra M, Uriarte I, Pineda-Lucena A, Prosper F, Berraondo P, Alonso C, Sangro B, García Marin JJ, Martinez-Chantar ML, Ciordia S, Corrales FJ, Francalanci P, Alaggio R, Zucman-Rossi J, Indersie E, Cairo S, Domingo-Sàbat M, Zanatto L, Sancho-Bru P, Armengol C,Berasain C, Fernandez-Barrena MG, Avila MA. Identification and experimental validation of druggable epigenetic targets in hepatoblastoma. J Hepatol. 2023 Oct;79(4):989-1005. doi: 10.1016/j.jhep.2023.05.031. Epub 2023 Jun 10. PMID: 37302584.
Lapitz A, Azkargorta M, Milkiewicz P, Olaizola P, Zhuravleva E, Grimsrud MM, Schramm C, Arbelaiz A, O’Rourke CJ, La Casta A, Milkiewicz M, Pastor T, Vesterhus M, Jimenez-Agüero R, Dill MT, Lamarca A, Valle JW, Macias RIR, Izquierdo-Sanchez L, Pérez Castaño Y, Caballero-Camino FJ, Riaño I, Krawczyk M, Ibarra C, Bustamante J, Nova-Camacho LM, Falcon-Perez JM, Elortza F, Perugorria MJ, Andersen JB, Bujanda L, Karlsen TH, Folseraas T, Rodrigues PM, Banales JM. Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. J Hepatol. 2023 Jul;79(1):93-108. doi: 10.1016/j.jhep.2023.02.027. Epub 2023 Mar 1. PMID: 36868481; PMCID: PMC10292605.
Juzenas S, Ellinghaus D, Sanna S, Franke A, D’Amato M. Mendelian randomisation shows diverticular disease and irritable bowel syndrome increase the risk of haemorrhoidal disease. Gut. 2023 Oct 9:gutjnl-2023-330364. doi: 10.1136/gutjnl-2023-330364. PMID: 37813565.
Zamfir-Taranu A, Löscher BS, Husein DM, Hoter A, Garcia-Etxebarria K, Etxeberria U, Gayoso L, Mayr G, Nilholm C, Gustafsson RJ, Ozaydin O, Zheng T, Esteban-Blanco C, Bozzarelli I, Bonfiglio F, Rizk S, Franke A, Bujanda L, Naim HY, Ohlsson B, D’Amato M. Sucrase-isomaltase genotype and response to a starch- reduced and sucrose-reduced diet in IBS-D patients. Gut. 2024 Mar 7;73(4):706-708. doi: 10.1136/gutjnl-2023-329695. PMID: 36878682.
Fittolani G, Tyrikos-Ergas T, Poveda A, Yu Y, Yadav N, Seeberger PH, Jiménez-Barbero J, Delbianco M. Synthesis of a glycan hairpin. Nat Chem. 2023 Oct;15(10):1461-1469. doi: 10.1038/s41557-023-01255-5. Epub 2023 Jul 3. PMID: 37400598; PMCID: PMC10533408.
Navarro S, Díaz-Caballero M, Peccati F, Roldán-Martín L, Sodupe M, Ventura S. Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes. ACS Nano. 2023 Sep 12;17(17):16968-16979. doi: 10.1021/acsnano.3c04164. Epub 2023 Aug 30. PMID: 37647583; PMCID: PMC10510724.
Lopez-Robles C, Scaramuzza S, Astorga-Simon EN, Ishida M, Williamson CD, Baños-Mateos S, Gil-Carton D, Romero-Durana M, Vidaurrazaga A, Fernandez-Recio J, Rojas AL, Bonifacino JS, Castaño-Díez D, Hierro A. Architecture of the ESCPE-1 membrane coat. Nat Struct Mol Biol. 2023 Jul;30(7):958-969. doi: 10.1038/s41594-023-01014-7. Epub 2023 Jun 15. PMID: 37322239; PMCID: PMC10352136.
Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJB, …, Matejcic M, Jenkins MA, Slattery ML, D’Amato M, …, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Guelpen B, Ulrich CM, Platz EA, Potter JD, Li CI, Meester R, Moreno V, Figueiredo JC, Casey G, Lansdorp Vogelaar I, Dunlop MG, Gruber SB, Hayes RB, Pharoah PDP, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L. Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations. Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0. PMID: 37783704; PMCID: PMC10545678.
Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R, Sutherland JD. BioE3 identifies specific substrates of ubiquitin E3 ligases. Nat Commun. 2023 Nov 23;14(1):7656. doi: 10.1038/s41467-023-43326-8. PMID: 37996419; PMCID: PMC10667490.
Lenza MP, Egia-Mendikute L, Antoñana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jiménez-Barbero J, Palazon A, Ereño-Orbea J. Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun. 2023 Jun 13;14(1):3496. doi: 10.1038/s41467-023-39119-8. PMID: 37311743; PMCID: PMC10264397.
Méndez Y, Vasco AV, Ivey G, Dias AL, Gierth P, Sousa BB, Navo CD, Torres- Mozas A, Rodrigues T, Jiménez-Osés G, Bernardes GJL. Merging the Isonitrile- Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process. Angew Chem Int Ed Engl. 2023 Oct 26;62(44):e202311186. doi: 10.1002/anie.202311186. Epub 2023 Sep 20. PMID: 37682023.
Chopra P, Yadavalli T, Palmieri F, Jongkees SAK, Unione L, Shukla D, Boons GJ. Synthetic Heparanase Inhibitors Can Prevent Herpes Simplex Viral Spread. Angew Chem Int Ed Engl. 2023 Oct 9;62(41):e202309838. doi: 10.1002/anie.202309838. Epub 2023 Sep 6. PMID: 37555536.
Marcos-Atanes D, Vidal C, Navo CD, Peccati F, Jiménez-Osés G, Mascareñas JL. Iridium-Catalyzed ortho-Selective Borylation of Aromatic Amides Enabled by 5-Trifluoromethylated Bipyridine Ligands. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202214510. doi: 10.1002/anie.202214510. Epub 2023 Jan 24. PMID: 36602092.
Lucien F, Gustafson D, Lenassi M, Li B, Teske JJ, Boilard E, von Hohenberg KC, Falcón-Perez JM, Gualerzi A, Reale A, Jones JC, Lässer C, Lawson C, Nazarenko I, O’Driscoll L, Pink R, Siljander PR, Soekmadji C, Hendrix A, Welsh JA, Witwer KW, Nieuwland R. MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research. J Extracell Vesicles. 2023 Dec;12(12):e12385. doi: 10.1002/jev2.12385. PMID: 38063210; PMCID: PMC10704543.
Bhaoighill MN, Falcón-Pérez JM, Royo F, Tee AR, Webber JP, Dunlop EA. Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers. J Extracell Vesicles. 2023 Jun;12(6):e12336. doi: 10.1002/jev2.12336. PMID: 37337371; PMCID: PMC10279809.
Brady M, Shchepetkina VI, González-Recio I, Martínez-Chantar ML, Buccella D. Ratiometric Fluorescent Sensors Illuminate Cellular Magnesium Imbalance in a Model of Acetaminophen-Induced Liver Injury. J Am Chem Soc. 2023 Oct 11;145(40):21841-21850. doi: 10.1021/jacs.3c05704. Epub 2023 Oct 2. PMID: 37782839; PMCID: PMC10571084.
Wang Z, Poveda A, Zhang Q, Unione L, Overkleeft HS, van der Marel GA, Jiménez-Barbero J, Codée JDC. Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1. FJ Am Chem Soc. 2023 Jun 28;145(25):14052-14063. doi: 10.1021/jacs.3c03976ragments.. Epub 2023 Jun 13. PMID: 37310804; PMCID: PMC10311536.
Méndez Y, Vasco AV, Ivey G, Dias AL, Gierth P, Sousa BB, Navo CD, Torres-Mozas A, Rodrigues T, Jiménez-Osés G, Bernardes GJL. Merging the Isonitrile- Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process. Angew Chem Int Ed Engl. 2023 Oct 26;62(44):e202311186. doi: 10.1002/anie.202311186. Epub 2023 Sep 20. PMID: 37682023.
Dal Forno GM, Latocheski E, Beatriz Machado A, Becher J, Dunsmore L, St John AL, Oliveira BL, Navo CD, Jiménez-Osés G, Fior R, Domingos JB, Bernardes GJL. Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions. J Am Chem Soc. 2023 May 17;145(19):10790-10799. doi: 10.1021/jacs.3c01960. Epub 2023 May 3. PMID: 37133984; PMCID: PMC10197128.
Goikoetxea-Usandizaga N, Bravo M, Egia-Mendikute L, Abecia L, Serrano-Maciá M, Urdinguio RG, Clos-García M, Rodríguez-Agudo R, Araujo-Legido R, López- Bermudo L, Delgado TC, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Peña-Cearra A, Simón J, Benedé-Ubieto R, Ariño S, Herranz JM, Azkargorta M, Salazar-Bermeo J, Martí N, Varela-Rey M, Falcón-Pérez JM, Lorenzo Ó, Nogueiras R, Elortza F, Nevzorova YA, Cubero FJ, Saura D, Martínez-Cruz LA, Sabio G, Palazón A, Sancho-Bru P, Elguezabal N, Fraga MF, Ávila MA, Bataller R, Marín JJG, Martín F, Martínez-Chantar ML. The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent. Hepatology. 2023 Sep 1;78(3):878-895. doi: 10.1097/HEP.0000000000000303. Epub 2023 Feb 9. PMID: 36745935; PMCID: PMC10442112.
Peñuelas-Haro I, Espinosa-Sotelo R, Crosas-Molist E, Herranz-Itúrbide M, Caballero-Díaz D, Alay A, Solé X, Ramos E, Serrano T, Martínez-Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression. Hepatology. 2023 Aug 1;78(2):416-433. doi: 10.1002/hep.32702. Epub 2022 Sep 17. PMID: 35920301; PMCID: PMC10344438.
Dumčius P, Mikhaylov R, Zhang X, Bareford M, Stringer M, Errington R, Sun C, Gonzalez E, Krukovski T, Falcon-Perez JM, Liang D, Fu YQ, Clayton A, Yang X. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small. 2023 Aug;19(35):e2300390. doi: 10.1002/smll.202300390. Epub 2023 Apr 28. PMID: 37118859.
Plou J, Valera PS, García I, Vila-Liarte D, Renero-Lecuna C, Ruiz-Cabello J, Carracedo A, Liz-Marzán LM. Machine Learning-Assisted High-Throughput SERS Classification of Cell Secretomes. Small. 2023 Dec;19(51):e2207658. doi: 10.1002/smll.202207658. Epub 2023 Apr 12. PMID: 37046181.