Highlighted Articles
Rueda-Alaña E, Senovilla-Ganzo R, Grillo M, Vázquez E, Marco-Salas S, Gallego-Flores T, Ordeñana-Manso A, Ftara A, Escobar L, Benguría A, Quintas A, Dopazo A, Rábano M, Vivanco MD, Aransay AM, Garrigos D, Toval Á, Ferrán JL, Nilsson M, Encinas-Pérez JM, De Pittà M, García-Moreno F. Science. 2025 Jan 2;387(6735):eadp3411. doi: 10.1126/science.adp3411. Epub 2025 Feb 14. PMID: 39946453 Cancer Heterogeneity Lab & Genome Analysis Platform
Martins Rodrigues F, Terekhanova NV, Imbach KJ, Clauser KR, Esai Selvan M, Mendizabal I, Geffen Y, Akiyama Y, Maynard M, Yaron TM, Li Y, Cao S, Storrs EP, Gonda OS, Gaite-Reguero A, Govindan A, Kawaler EA, Wyczalkowski MA, Klein RJ, Turhan B, Krug K, Mani DR, Leprevost FDV, Nesvizhskii AI, Carr SA, Fenyö D, Gillette MA, Colaprico A, Iavarone A, Robles AI, Huang KL, Kumar-Sinha C, Aguet F, Lazar AJ, Cantley LC, Marigorta UM, Gümüş ZH, Bailey MH, Getz G, Porta-Pardo E, Ding L; Clinical Proteomic Tumor Analysis Consortium. Cell. 2025 May 1;188(9):2312-2335.e26. doi: 10.1016/j.cell.2025.03.026. Epub 2025 Apr 14. PMID: 40233739; PMCID: PMC12326532. Integrative Genomics Lab
Jabalera Y, Tascón I, Samperio S, López-Alonso JP, Gonzalez-Lopez M, Aransay AM, Abascal-Palacios G, Beisel CL, Ubarretxena-Belandia I, Perez-Jimenez R. Nat Biotechnol. 2025 Oct;43(10):1663-1672. doi: 10.1038/s41587-024-02461-3. Epub 2024 Oct 31. PMID: 39482449. Synthetic Biology Lab & Genome Analysis Platform
Priego N, de Pablos-Aragoneses A, Perea-García M, Pieri V, Hernández-Oliver C, Álvaro-Espinosa L, Rojas A, Sánchez O, Steindl A, Caleiras E, García F, García-Martín S, Graña-Castro O, García-Mulero S, Serrano D, Velasco-Beltrán P, Jiménez-Lasheras B, Egia-Mendikute L, Rupp L, Stammberger A, Meinhardt M, Chaachou-Charradi A, Martínez-Saez E, Bertero L, Cassoni P, Mangherini L, Pellerino A, Rudà R, Soffietti R, Al-Shahrour F, Saftig P, Sanz-Pamplona R, Schmitz M, Crocker SJ, Calvo A, Palazón A; RENACER; Valiente M. Cancer Discov. 2025 Jan 13;15(1):179-201. doi: 10.1158/2159-8290.CD-24-0134. PMID: 39354883; PMCID: PMC11726018. Cancer Immunology & Immunotherapy lab
Córdoba KM, Jericó D, Jiang L, Collantes M, Alegre M, García-Ruiz L, Manzanilla O, Sampedro A, Herranz JM, Insausti I, Martinez de la Cuesta A, Urigo F, Alcaide P, Morán M, Martín MA, Lanciego JL, Lefebvre T, Gouya L, Quincoces G, Unzu C, Hervas-Stubbs S, Falcón-Pérez JM, Alegre E, Aldaz A, Fernández-Seara MA, Peñuelas I, Berraondo P, Martini PGV, Avila MA, Fontanellas. Gut. 2025 Jan 17;74(2):270-283. doi: 10.1136/gutjnl-2024-332619. PMID: 39366725; PMCID:
PMC11874285. Exosomes Lab
Elurbide J, Colyn L, Latasa MU, Uriarte I, Mariani S, Lopez-Pascual A, Valbuena E, Castello-Uribe B, Arnes-Benito R, Adan-Villaescusa E, Martinez-Perez LA, Azkargorta M, Elortza F, Wu H, Krawczyk M, Schneider KM, Sangro B, Aldrighetti L, Ratti F, Casadei Gardini A, Marin JJG, Amat I, Urman JM, Arechederra M, Martinez-Chantar ML, Trautwein C, Huch M, Cubero FJ, Berasain C, G Fernandez-Barrena M, Avila MA. Gut. 2024 Dec 10;74(1):116-127. doi: 10.1136/gutjnl-2024-332998. PMID: 39266051; PMCID: PMC12056590. Liver Disease Lab & Proteomics Platform
Grännö O, Bergemalm D, Salomon B, Lindqvist CM, Hedin CRH, Carlson M, Dannenberg K, Andersson E, Keita ÅV, Magnusson MK, Eriksson C, Lanka V; BIOIBD consortium; Magnusson PKE, D’Amato M, Öhman L, Söderholm JD, Hultdin J, Kruse R, Cao Y, Repsilber D, Grip O, Karling P, Halfvarson J. Gastroenterology. 2025 Apr;168(4):741-753. doi: 10.1053/j.gastro.2024.11.006. Epub 2024 Nov 26. PMID: 39608683.
Gastrointestinal Genetics Lab
Ji Z, Mukherjee S, Andreo J, Sinelshchikova A, Peccati F, Jiménez-Osés G,
Wuttke S, Boxer SG.. Nat Chem. 2025 Dec;17(12):1920-1927. doi: 10.1038/s41557-025-01916-7. Epub 2025 Aug 27. PMID: 40866609; PMCID: PMC12473737. Computational Chemistry Lab
Soto-Heredero G, Gabandé-Rodríguez E, Carrasco E, Escrig-Larena JI, Gómez de Las Heras MM, Delgado-Pulido S, Francos-Quijorna I, Blanco EM, Fernández-Almeida Á, Abia D, Rodríguez MJ, Fernández-Díaz CM, Álvarez-Flores MB, Ramírez de Molina
A, Jung S, Del Sol A, Zorita V, Sánchez-Cabo F, Torroja C, Mittelbrunn M. Nat Aging. 2025 May;5(5):799-815. doi: 10.1038/s43587-025-00855-9. Epub 2025 Apr 30. PMID: 40307497; PMCID: PMC12092250. . Computational Biology Lab
Liutkus M, Rojas AL, Cortajarena AL. Angew Chem Int Ed Engl. 2025 Dec8;64(50):e202516635. doi: 10.1002/anie.202516635. Epub 2025 Oct 12. PMID: 41077847. Electron Microscopy and Macromolecular Crystallography Platforms
Østerlid KE, Li S, Unione L, Bino LD, Sorieul C, Carboni F, Berni F, Bertuzzi S, van Puffelen B, Arda A, Overkleeft HS, van der Marel GA, Romano MR, Jiménez- Barbero J, Adamo R, Codée JDC. Angew Chem Int Ed Engl. 2025 Sep 22;64(39):e202511378. doi: 10.1002/anie.202511378. Epub 2025 Aug 18. PMID: 40823959; PMCID: PMC12455396.
Chemical Glycobiology Lab
Cosottini L, Giachetti A, Guerri A, Martinez-Castillo A, Geri A, Zineddu S, Abrescia NGA, Messori L, Turano P, Rosato A. Angew Chem Int Ed Engl. 2025 Jul 21;64(30):e202503778. doi: 10.1002/anie.202503778. Epub 2025 Apr 27. PMID: 40249912; PMCID: PMC12281091 Structure & Cell Biology of Viruses Lab
Zapata-Pavas LE, Serrano-Macia M, Merlos Rodrigo MÁ, Barrenechea-Barrenechea JA, Peña-SanFelix P, Del Río-Álvarez Á, Gil-Pitarch C, Rejano-Gordillo CM, Goikoetxea-Usandizaga N, González-Recio I, Michalkova H, Mercado-Gómez M, Lachiondo-Ortega S, Castañeda A, Asensio M, Murti A, Lelou E, Nogueiras R, Mayor U, Heger Z, Sancho-Bru P, Delgado TC, Calvisi DF, Xirodimas DP, Wang B, Marin JJG, Fernandez-Barrena MG, Armengol C, Ávila M, Martínez-Chantar ML. Hepatology. 2025 Nov 14. doi: 10.1097/HEP.0000000000001614. Epub ahead of print. PMID: 41236496
Liver Disease Lab
Apodaka-Biguri M, Simão AL, González-Romero F, Mestre D, Rodrigues PM, Aurrekoetxea I, Gómez-Santos B, Buqué X, Nieva-Zuluaga A, de Gauna MR, Fernandez-Puertas I, Gomez-Jauregui P, Sainz-Ramirez N, Alfaro-Jiménez K, Ortiz- Palma A, Castillero E, Iglesias-Ara A, Mitxelena J, Eriz A, Aransay AM, Lozano JJ, Marin JJG, Izquierdo-Sanchez L, Perugorria MJ, Bujanda L, Banales JM, Martín C, Mosteiro L, Errazti G, Syn WK, Castaño L, Zubiaga AM, Castro RE, Aspichueta P. E2F2 transcription factor promotes a cholestatic MASH phenotype by regulating hepatobiliary metabolism through miR-34a-5p. Hepatology. 2025 Jul 28. doi: 10.1097/HEP.0000000000001461. Epub ahead of print. PMID: 40720724. Genome Analysis Platform
Olaizola P, Olaizola I, Fernandez de Ara M, Lapitz A, Val B, Izquierdo-Sanchez L, Fernandez-Barrena MG, Alvarez L, O’Rourke CJ, Lee-Law PY, Davies K, Gradinaru A, Jimenez-Agüero R, La Casta A, Riaño I, Macias RIR, Marin JJG,
Martinez-Chantar ML, Avila MA, Aspichueta P, Andersen JB, Boulter L, Bujanda L, Rodrigues PM, Perugorria MJ, Banales JM. Hepatology. 2025 Dec 1;82(6):1461-1479. doi:
Liver Disease Lab
Nóvoa E, da Silva Lima N, Gonzalez-Rellan MJ, Chantada-Vazquez MDP, Verheij J, Rodriguez A, Esquinas-Roman EM, Fondevila MF, Koning M, Fernandez U, Cabaleiro A, Parracho T, Iglesias-Moure J, Seoane S, Porteiro B, Escudero A, Senra A, Perez-Fernandez R, López M, Fidalgo M, Guallar D, Martinez-Chantar ML, Dieguez C, Varela-Rey M, Prevot V, Schwaninger M, Meijnikman A, Bravo SB, Frühbeck G, Nogueiras R. Hepatology. 2025 May
1;81(5):1535-1552. doi: 10.1097/HEP.0000000000000930. Epub 2024 May 16. PMID: 38761407; PMCID: PMC11999095.
Liver Disease Lab
Yadav N, Poveda A, Vázquez Mena Y, Rosenthal M, Ogawa Y, Jiménez-Barbero J, Delbianco M.. J Am Chem Soc. 2025 May 7;147(18):15126-15135. doi: 10.1021/jacs.4c17992. Epub 2025 Apr 24. PMID: 40273339; PMCID: PMC12063165. Chemical Glycobiology Lab
Østerlid KE, Sorieul C, Unione L, Li S, García-Sepúlveda C, Carboni F, Del Bino L, Berni F, Arda A, Overkleeft HS, van der Marel GA, Romano MR, Jiménez-
Barbero J, Adamo R, Codée JDC. LongJ Am Chem Soc. 2025 Jan 22;147(3):2829-2840. doi:
10.1021/jacs.4c16118. Epub 2025 Jan 10. PMID: 39792791; PMCID: PMC11760181. Chemical Glycobiology Lab
Becher JB, Dutta N, Navo CD, Dunsmore L, Misteli R, Gil de Montes E, Simpson GG, Alewine CC, Jiménez-Osés G, Bernardes GJL. J Am Chem Soc. 2025 Dec 31;147(52):48271-48289. doi: 10.1021/jacs.5c17598. Epub 2025 Dec 14. PMID: 41392458; PMCID: PMC12766730. Computational Chemistry Lab
Gamarra M, Cruz-Gambra A, Blanco-Urrejola M, González E, Azkargorta M, Elortza F, Falcón-Pérez JM, Baleriola J. J Extracell Vesicles. 2025 Dec;14(12):e70216. doi: 10.1002/jev2.70216. PMID: 41416952; PMCID: PMC12716141 Exosomes Lab & Proteomics Platform
Hernandez P, Rackles E, Alboniga OE, Martínez-Lage P, Camacho EN, Onaindia A, Fernandez M, Talamillo A, Falcon-Perez JM. J Extracell Vesicles. 2025 Feb;14(2):e70043. doi: 10.1002/jev2.70043. PMID: 39901643; PMCID: PMC11791017. Exosomes Lab
Santamaria G, Iglesias C, Jung S, Arcos Hodar J, Nogueiras R, Del Sol A. Adv Sci (Weinh). 2025 Oct;12(37):e03344. doi: 10.1002/advs.202503344.
Epub 2025 Jul 14. PMID: 40660726; PMCID: PMC12499397. Computational Biology Lab
Marcos-Atanes D, Jiménez-Osés G, Mascareñas JL.. ACS Catal. 2025 Apr 16;15(9):7112-7120. doi: 10.1021/acscatal.5c00933. PMID:
40463519; PMCID: PMC12128192. Computational Chemistry Lab
Cardoso Delgado T, Martín-Cuevas C, Sánchez Hidalgo AC, Gil Gómez A, Rejano Gordillo CM, Landa J, Gallego Durán R, Goikoetxea-Usandizaga N, González-Recio I, Gil-Pitarch C, Zapata-Pavas LE, Barrenechea-Barrenechea JA, Conter C, Martínez-Cruz LA, Ramos Herrero VD, Nogueiras R, Azkargorta M, Elortza F, Moncho-Amor V, Crespo J, Matheu A, Romero Gómez M, Crespo-Facorro B, Martínez- Chantar ML. Sci Adv. 2025 Oct 24;11(43):eady9758. doi: 10.1126/sciadv.ady9758. Epub 2025 Oct 22. PMID: 41124271; PMCID: PMC12542958. . Liver Disease Lab & Proteomics Platform
Jabalera Y, Dahiya D, Cencerrado CDO, Caballero AJ, Zaldua N, Eceiza A, Master ER, Perez-Jimenez R. Carbohydr Polym. 2025 Jun 1;357:123469. doi:10.1016/j.carbpol.2025.123469. Epub 2025 Mar 3. PMID: 40158993. Synthetic Biology Lab
Zamfir-Taranu A, Löscher BS, Carbone F, Hoter A, Esteban Blanco C, Bozzarelli
I, Torices L, Routhiaux K, Van den Houte K, Bonfiglio F, Mayr G, Corsetti M, Naim HY, Franke A, Tack J, D’Amato MClin Gastroenterol Hepatol. 2025 Jun;23(7):1228-1237.e10. doi: 10.1016/j.cgh.2024.09.004. Epub 2024 Oct 14. PMID: 39413891 Gastrointestinal Genetics Lab
Barbier-Torres L, Luque-Urbano M, Chhimwal J, Robinson AE, Fernández-Ramos D, Lopitz-Otsoa F, Van Eyk JE, Millet O, Mato JM, Lu SC. Metabolism. 2025 Apr;165:156154. doi: 10.1016/j.metabol.2025.156154. Epub 2025 Feb 6. PMID:
39922455; PMCID: PMC12036799. Precision Medicine and Metabolism Lab
Cernauskiene I, Navo CD, Labão-Almeida C, J Proctor RS, Gless BH, Khaw WT, Tang C, Muriel-Olaya MM, Jiménez-Osés G, Bernardes GJL. J Am Chem Soc. 2025 Jul 16;147(28):24691-24698. doi: 10.1021/jacs.5c05952. Epub
Computational Chemistry Lab
A basic framework to explain splice-site choice in eukaryotes.
Dent CI, Prodic S, Balakrishnan A, Chhabra A, Georges JDG, Mukherjee S, Coutts J, Gitonobel M, Sarwade RD, Rosenbluh J, D’Amato M, Das PP, Guo YL, Fournier-Level A, Burke R, Sureshkumar S, Powell D, Balasubramanian S. Nat Commun. 2025 Sep 29;16(1):8284. doi: 10.1038/s41467-025-63622-9. PMID: 41022769; PMCID: PMC12480690. Gastrointestinal Genetics Lab https://www.nature.com/articles/s41467-025-63622-9
Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis.
Martínez García de la Torre RA, Vallverdú J, Xu Z, Ariño S, Ferrer-Lorente R, Zanatto L, Mercado-Gómez M, Aguilar-Bravo B, Ruiz-Blázquez P, Fernandez- Fernandez M, Navarro-Gascon A, Blasco-Roset A, Sànchez-Fernàndez-de-Landa P, Pera J, Romero-Moya D, Ayuso Garcia P, Martínez Sánchez C, Sererols Viñas L, Cantallops Vilà P, Cárcamo Giráldez CI, McQuillin A, Morgan MY, Moya-Rull D, Montserrat N, Eberlé D, Staels B, Antoine B, Azkargorta M, Lozano JJ, Martínez- Chantar ML, Giorgetti A, Elortza F, Planavila A, Varela-Rey M, Woodhoo A, Zorzano A, Graupera I, Moles A, Coll M, Affo S, Sancho-Bru P. Nat Commun. 2025 Feb 10;16(1):1489. doi:
10.1038/s41467-025-56024-4. PMID: 39929812; PMCID: PMC11811062. Liver Disease Lab & Proteomics Platform https://www.nature.com/articles/s41467-025-56024-4
Connectivity of the adult human brain with sequential neurogenesis of circuits and transcriptomics signatures.
Diez I, García-Moreno F, Carral-Sainz N, Stramaglia S, Nieto-Reyes A, D’Amato M, Cortes JM, Bonifazi P. Nat Commun. 2025 Dec 31;17(1):1035. doi: 10.1038/s41467-025-67785-3. PMID: 41476060; PMCID: Gastrointestinal Genetics Lab
https://www.nature.com/articles/s41467-025-67785-3